Bone & Mineral Metabolism
Considered a major public health threat to an estimated 44 million Americans or 55 percent of people age 50 and older, osteoporosis has been reported in people of all ethnic backgrounds.
Source: National Osteoporosis Foundation
- Osteoporosis leads to bone fragility and increased susceptibility to fractures of the hip, spine and wrist, causing bones to weaken and break from minor falls or simple actions, such as a sneeze.
- The number of fractures attributed to osteoporosis is expected to rise to over 3 million by 2025.
- Women comprise an estimated 80 percent of patients with this disease, characterized by low bone mass and structural deterioration of bone tissue.
- The condition remains under-recognized and under-treated in Caucasian and African American women, and risk is increasing most rapidly among Hispanic women.
- Bones are metabolically very active, rebuilding bone structure, producing red and white blood cells and producing hormones that can affect other bodily functions and may even play a role in developing diabetes and obesity.
For decades, Winthrop-University Hospital has been internationally recognized as a leader in osteoporosis research, with supporting grants from many sources, including the National Institutes of Health and the pharmaceutical industry. The Hospital�s bone mineral specialists conduct basic science and clinical bone metabolism studies, examining pathogenic mechanisms responsible for the development of skeletal fragility and osteoporosis.
WUH Researchers� Study:
- Effects of calcium and estrogen on bone mass and body composition in an ethnically diverse population
- Use of vitamin D in elderly African-American women.
- Effects of growth hormone on bone metabolism.
- Novel approaches towards the treatment of painful osteoporotic vertebral compression fractures.
- new treatments such as percutaenous lumbar decompression
- the metabolism and regulation of bone formation and resorption activities via bone histomorphometric and microscopic image analysis
- the pathogenesis and cellular mechanisms of metabolic bone diseases
- rodent models of osteoporosis to evaluate the efficacy of hormonal therapy and nutritional supplementation.
- Effects of green tea�s polyphenols and antioxidatives on bone health
Faculty who study Bone & Mineral Metabolism:
John Aloia, M.D.
Mariano Castro-Magano, M.D.
Jodi Evans, Ph.D.
Mageda Mikhail, MD
Orlando Ortiz, M.D.
Morgan Peltier, Ph.D.
Namji YU, M.D.