Melissa Fazzari, PhD
Director of Biostatistics
Academic Faculty Appointments
Associate Professor of Research Preventive Medicine, Stony Brook University
Research and Academic Center, 101 Mineola Blvd, Suite 3-041
Dr. Fazzari serves as the Director of Biostatistics for Winthrop-University Hospital. Dr. Melissa Fazzari obtained her Ph.D. in Applied Mathematics and Statistics from Stony Brook University, and a B.A. in Mathematics from Boston University. Previously, she was an Assistant Professor in the Department of Preventive Medicine at Stony Brook University and in the Departments of Epidemiology and Genetics at Albert Einstein College of Medicine. Dr. Fazzari also currently collaborates with researchers at Mount Sinai developing prognostic models using methylation and gene expression data to predict treatment response and other patient outcomes in Mantle Cell Lymphoma.
Description of Research Interests/Activities
Dr. Fazzari's background includes 15 years' experience as a biostatistician for major research projects involving cancer, epigenomics, and the epidemiology of HPV progression in a large study of HIV-positive women. Dr. Fazzari developed sample size formulae for three-level hierarchical clinical trials and has explored the robustness of these formulae to common issues in clinical trials: missing data and group imbalances. Dr. Fazzari has expertise in the analysis, aggregation, and integration of data from high dimensional epigenome-wide studies, developing a prioritization approach to incorporate biological priors with statistical testing in order to better identify novel candidate loci.
Areas of Experience
Research Team Members
The Biostatistics team consists of three Biostatisticians. Melissa Fazzari, Ph.D., Shah Islam, M.S. and Rose Calixte, Ph.D.
Clinical Practice and Interests
1. Fazzari M, Heller G, Scher HI. The phase II/III transition. Toward the proof of efficacy in cancer clinical trials. Controlled Clinical Trials, Aug 2000, 21(4) p360-8 [PMID: 10913810]
2. Mazumdar M, Fazzari M, Panageas KS. A standardization method to adjust for the effect of patient selection in phase II clinical trials. Statistics in Medicine, Mar 30 2001, 20(6) p883-92 [PMID: 11252010]
3. Fazzari MJ, Greally JM. Epigenomics: Beyond CpG Islands. Nature Reviews Genetics 5, 446 - 455 (2004) [PMID: 15153997]
4. Sparano J, Fazzari M, Childs J. Clinical application of molecular profiling in breast cancer. Future Oncology (2005); 1(4):485-496.[PMID: 16556025]
5. Ahn, H., Moon, H., Fazzari, MJ., Lim, N., Chen, J. J. and Kodell, R. L. Classification by Ensembles of Random Partitions. Computational Statistics and Data Analysis (2006); 51(12):6166-6179.
6.Strickler HD, Fazzari M, Kovacs A, Isasi C, Napolitano LA, Minkoff H, Gange S, Young M, Sharp GB, Kaplan RC, Cohen M, Gunter MJ, Harris TG, Yu H, Schoenbaum E, Landay AL, Anastos K. Associations of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3 with HIV Disease Progression in Women. J Infect Dis. (2008); 197(2):319-27 [PMID: 18177247]
7.Chow JC, Ciaudo C, Fazzari MJ, Mise N, Servant N, Glass JL, Attreed M, Avner P, Wutz A, Barillot E, Greally JM, Voinnet O, Heard E LINE1 activity in facultative heterochromatin formation during X-chromosome inactivation Cell. 2010 Jun 11;141(6):956-69.[PMID: 20550932]
8.Fazzari, MJ and Greally JM. Introduction to Epigenomics and Epigenome-wide analysis. Methods Mol Biol. (2010);620:243-65 [PMID: 20652507]
9. Kenny P, Fazzari MJ, Sparano, J. Clinical Application of Gene Expression Profiling in Breast Cancer, Surg Oncol Clin N Am (2010)
10. Fazzari, M. Prioritization of candidate loci in epigenome-wide methylation studies. JSM Proceedings (2009), Biometrics section. Alexandria, VA: American Statistical Association.
11. Childs G, Fazzari M, Kung G, Kawachi N, Brandwein-Gensler M, McLemore M, Chen Q, Burk RD, Smith RV, Prystowsky M, Belbin TJ, Schlecht NF. Low level expression of microRNA's let7-d and miR-205 are prognostic markers of head and neck squamous cell carcinoma. AJP (2009); Mar;174(3):736-45
12. Prazak KA, Lester PE, Fazzari M. Evaluation of Physician Assistant Student Knowledge and Perception of Competence in Palliative Symptom Management. J Allied Health. 2014 Winter;43(4):e69-e74.PMID:25433191
13. Adams TM, Kinzler WL, Chavez MR, Fazzari MJ, Vintzileos AM. Practice patterns in the timing of antenatal corticosteroids for fetal lung maturity. J Matern Fetal Neonatal Med. 2014 Sep 29:1-4. PMID: 25189992
14. Fazzari MJ, Kim MY, Heo M. Sample size determination for three-level randomized clinical trials with randomization at the first or second level. J Biopharm Stat. 2014;24(3):579-99. PMID:24697506
15. Kuo PY, Leshchenko VV, Fazzari MJ, Perumal D, Gellen T, He T, Iqbal J, Baumgartner-Wennerholm S, Nygren L, Zhang F, Zhang W, Suh KS, Goy A, Yang DT, Chan WC, Kahl BS, Verma AK, Gascoyne RD, Kimby E, Sander B, Ye BH, Melnick AM, Parekh S. High-resolution chromatin immunoprecipitation (ChIP) sequencing reveals novel binding targets and prognostic role for SOX11 in mantle cell lymphoma.
Oncogene. 2014 Mar 31;0.PMID:24681958