Thomas M. Jeitner, PhD
Lead Scientist Winthrop University Hospital Research Institute
Academic Faculty Appointments
Assistant Professor, Department of Medicine, Stony Brook University
222 Station Plaza North, Suite 502, Mineola NY 11501
Jeitner, a native of Australia, earned a doctorate in experimental pathology from the University of Sydney. He has held positions at numerous institutions in the US.
Description of Research Interests/Activities
Tom Jeitner has a long-standing interest in the mechanisms by which neurons die. Neurons in the brain are protected from injury by the skull and blood-brain barrier, as well as, the actions of astrocytes and microglial. Similar protections exist for spinal cord neurons. Despite these barriers the central nervous system is vulnerable to variety of insults that can give rise to illnesses as devastating as Amyotrophic Lateral Sclerosis, Parkinson Disease and Alzheimer Disease. The laboratory is investigating the hypothesis that the diseased and aging brain generates neurotoxins through the reaction of hypohalous acids with neurotransmitters. Thus far, our studies have focused on the reaction of dopamine and hypochlorous acid as shown in the model below.
Areas of Experience
Research Team Members
Shishir Sinha, M.D.: Fellow
Joshua Hall: Undergraduate Student
Anjali Agarwalla: High School Student
Jeitner TM, John T. Pinto JT, Boris F. Krasnikov BF, Horswill M Cooper AJL (2009) Transglutaminases and Neurodegeneration. Journal of Neurochemistry 109 Suppl 1:160-6. Review
Jeitner TM, Muma NA, Bataile KP, Cooper AJLM (2009) Transglutaminase activation in neurodegenerative diseases. Future Medicine 4:449-467
Pinto, J. T., Khomenko, T., Szabo, S., McLaren, G. D., Denton, T. T., Krasnikov, B. F., Jeitner, T. M. and Cooper, A. J. (2009) Measurement of sulfur-containing compounds involved in the metabolism and transport of cysteamine and cystamine. Regional differences in cerebral metabolism. J Chromatogr B Analyt Technol Biomed Life Sci.
Milkevitch, M., Jeitner, T. M., Beardsley, N. J. and Delikatny, E. J. (2007) Lovastatin enhances phenylbutyrate-induced MR-visible glycerophosphocholine but not apoptosis in DU145 prostate cells. Biochim Biophys Acta, 1771, 1166-1176.
Jeitner, T. M., Matson, W. R., Folk, J. E., Blass, J. P. and Cooper, A. J. (2008) Increased levels of gamma-glutamylamines in Huntington disease CSF. J Neurochem, 106, 37-44.
Jeitner, T. M., Delikatny, E. J., Ahlqvist, J., Capper, H. and Cooper, A. J. (2005) Mechanism for the inhibition of transglutaminase 2 by cystamine. BiochemPharmacol, 69, 961-970
Jeitner, T. M., Xu, H. and Gibson, G. E. (2005) Inhibition of the alpha-ketoglutarate dehydrogenase complex by the myeloperoxidase products, hypochlorous acid and mono-N-chloramine. J Neurochem, 92, 302-310.
Pinto, J. T., Van Raamsdonk, J. M., Leavitt, B. R., Hayden, M. R., Jeitner, T. M., Thaler, H. T., Krasnikov, B. F. and Cooper, A. J. (2005) Treatment of YAC128 mice and their wild-type littermates with cystamine does not lead to its accumulation in plasma or brain: implications for the treatment of Huntington disease. J Neurochem, 94, 1087-1101.
The laboratory offers a variety of opportunities related to the aforementioned research interests. Where possible, we try include studies of human tissues and the involvement of physicians.