Lawrence E. Shapiro, MD
Chief, Division of Endocrinology, Diabetes and Metabolism
Director, Fellowship Program
Academic Faculty Appointments
Professor of Medicine, SUNY Stony Brook School of Medicine
1300 Franklin Avenue, suite ML6, Garden City, NY 11530
Dr. Lawrence Shapiro graduated from Downstate Medical School and trained in internal medicine at Bellevue-NYU Medical Center. He completed a two year clinical fellowship at NYU Bellevue followed by two post graduate years as an Associate Attending in the laboratory of Dr. Herbert Samuels at NYU, studying the regulation of the Growth Hormone gene by thyroid hormone. Dr. Shapiro joined the faculty of Montefiore Medical Center as an assistant professor and key faculty member where he established his own laboratory with an RO1 award to study the regulation of somatomedin by growth hormone in cultured chick fibroblast cultures. While at Montefiore he joined the laboratory of Dr. Martin Surks where he studied thyroid hormone action in collaboration with Dr. Surks. Dr Shapiro functioned as Key Teaching Faculty in the Endocrine Training Program and was promoted to Associate Professor of Medicine at AECOM. In 1995 Dr. Shapiro moved to New York Medical College where he was the Director of Endocrinology, Diabetes and Metabolism at Lincoln Mental and Medical Health Center. He was also Associate Director of Endocrinology and Professor of Medicine at New York Medical College. In 1999 Dr. Shapiro joined Winthrop University Hospital as Chief of the division of Endocrinology, Diabetes and Metabolism and Professor of Medicine at SUNY Stony Brook School of Medicine. Dr. Shapiro is author or co-author of 40 referred publications and 9 chapters in review concentrating in basic and clinical endocrinology. He is a "sought after" endocrinologist who has been awarded the distinction of “Top Doctor” in New York Magazine and Newsday. In 2008 he was named Physician of the Year by The Metropolitian New York Association of Diabetes Educators, a chapter of The American Association of Diabetes Educators.
Description of Research Interests/Activities
Dr. Shapiro's current research projects include clinical auto immune thyroid disease, endothelial dysfunction in type 2 diabetes, the pathophysiology of renal disease in obese individuals, and the regulation of adipose tissue lipocalin D2 Synthase in obese individuals with and without diabetes, and the regulation of thyroid nodular formation by vitamin D in patients with vitamin D insufficiency.
Areas of Experience
Auto Immune Thyroid Disease
Clinical Practice and Interests
Endocrinology, Diabetes and Thyroid disorders.
1. Shapiro LE, Samuels HH, Yaffe BM. Thyroid and glucocorticoid hormones synergistically control growth hormone mRNA in cultured GH1 cells. Proc Natl Acad Sci U S A. 1978 Jan;75(1):45-9.
2. Shapiro LE, Sachchidananda J. Regulation of proteins by thyroid hormone and glucocorticoid: the responses of hepatic alpha 2U-globulin and pituitary growth hormone differ in adult male hypothyroid rats. Endocrinology. 1982 Aug;111(2):653-60.
3. Shapiro LE. Regulation of a thyroid hormone-dependent protein by growth hormone: the induction of hepatic alpha 2U globulin and its messenger ribonucleic acid in adult male hypothyroid rats. Endocrinology. 1983 Oct;113(4):1280-6.
4. Shapiro LE, Patel KR, Surks MI. The rate of appearance of thyroid hormone nuclear receptor is increased during deoxyribose nucleic acid synthesis in GC cells: analysis of thymidine-treated GC cells using dense amino acid labeling. Endocrinology. 1986 Nov;119(5):2076-81.
5. Shapiro LE, Wagner N. Growth of H-35 rat hepatoma cells in unsupplemented serum-free media: effect of transferrin, insulin and cell density. In Vitro Cell Dev Biol. 1988 Apr;24(4):299-303.
6. Shapiro LE, Wagner N. Transferrin is an autocrine growth factor secreted by Reuber H-35 cells in serum-free culture. In Vitro Cell Dev Biol. 1989 Jul;25(7):650-4.
7. Shapiro LE, Katz CP, DeFesi CR, Surks MI. Heat shock of cultured GC cells enhances the level of triiodothyronine induced growth hormone (GH) and GH messenger ribonucleic acid. Endocrinology. 1989 Jul;125(1):180-5.
8. Reynolds AM, Surks MI, Shapiro LE. The effects of chronic exposure to supraphysiological concentrations of 3, 5, 3' triiodo-L-thyronine (T3) on cultured GC cells. J Cell Physiol. 1991 Dec;149(3):544-7.
9. Mokshagundam S, Shapiro LE, Surks MI. Heat stress of cultured GC cells enhances triiodothyronine-induced growth hormone production by action within the 5'-flanking region of the rat growth hormone gene. Biochem Biophys Res Commun. 1992 Oct 30;188(2):638-43.
10. Hupart KH, Hodin RA, Lazar MA, Shapiro LE, Chin WW, Surks MI. c-erb-A mRNA correlates with T3-receptor levels in liver and pituitary of tumor rats. Thyroid. 1993 Spring;3(1):55-8.
11. Shapiro LE, Katz CP, Wasserman SH, DeFesi CR, Surks MI. Heat stress and hydrocortisone are independent stimulators of triiodothyronine-induced growth hormone production in cultured rat somatotrophic tumour cells. Acta Endocrinol (Copenh). 1991 Apr;124(4):417-24.
12. Halperin Y, Shapiro LE, Surks MI. Down-regulation of type II L-thyroxine, 5'-monodeiodinase in cultured GC cells: different pathways of regulation by L-triiodothyronine and 3,3',5'-triiodo-L-thyronine. Endocrinology. 1994 Oct;135(4):1464-9.
13. Shapiro LE, Sievert R, Ong L, Ocampo EL, Chance RA, Lee M, Nanna M, Ferrick K, Surks MI. Minimal cardiac effects in asymptomatic athyreotic patients chronically treated with thyrotropin-suppressive doses of L-thyroxine. J Clin Endocrinol Metab. 1997 Aug;82(8):2592-5.
14. Lalani AP, Kanna B, John J, Ferrick KJ, Huber MS, Shapiro LE. Abnormal signal-averaged electrocardiogram (SAECG) in obesity. Obes Res. 2000 Jan;8(1):20-8.
15. Aytug S, Reich D, Shapiro LE, Bernstein D, Begum N. Imparied IRS-1/P13-Kinase signaling in patients with HCV; a mechanism for increased prevalence of type 2 diabetes. Hepatology Vol. 38 No. 6 1384-92, 2003.
Dr. Shapiro's current research is integrated with the Fellowship Training program in Endocrinology, Diabetes and Metabolism, which he directs, at Winthrop-University Hospital.