Harold Brem, MD, FACS
Chief, Division of Wound Healing and Regenerative Medicine
Academic Faculty Appointments
1998 to 3/2004: Assistant Professor, Department of Surgery
Mount Sinai School of Medicine, New York, New York
4/04-06/06 Assistant Professor of Surgery, Department of Surgery
Columbia University College of Physicians
04/04-04/08 Director Wound Healing Program
Columbia University Medical Center
07/06 -04/08 Associate Professor of Surgery, Department of Surgery
Columbia University College of Physicians & Surgeons
04/08-05/11 Chief, Division of Wound Healing and Regenerative Medicine
Associate Professor of Surgery & Pathology
Department of Surgery, New York University School of Medicine
Present: Candidate for Professor of Surgery, Stony Brook University School of Medicine
259 First Street, Mineola NY 11501
Harold Brem received his B.S. in General Science from Brandeis University, and M.D. from McGill University Medical School. His background includes five years at Harvard Medical School, where he worked in the research lab of Dr. Judah Folkman, collaborating directly with Dr. Folkman on investigations into the role of angiogenesis (blood vessel growth), cell biology and regenerative medicine (the use of growth factors and stem cells) in promoting wound healing. Dr. Brem has been practicing medicine in the vicinity of New York City for the past 13 years, with his major medical focus resting on decreasing and ultimately preventing the incidence and prevalence of diabetic foot ulcers and subsequent limb amputation, supported by his publishing of over 100 peer-reviewed articles and book chapters.
Over the past 10 years, Dr. Brem as received awards from the National Institute of Health (NIH) as well as the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), securing numerous research awards totaling several millions of dollars for supporting institutions in which he has worked, focusing on clinical trials and angiogenesis amongst other research disciplines.
Dr. Brem joined the Winthrop University Hospital team in 2011, where he assumed the role of Chief of the Division of Wound Healing and Regenerative Medicine. As Division Chief, he continues to work within his capacity as a world class wound surgeon while mentoring junior faculty, growing an outpatient clinic, and continuing groundbreaking wound research.
Description of Research Interests/Activities
Dr. Brem's research is focused on the healing of chronic wounds, found primarily in the elderly, diabetic, and very ill. His major research interests are detailed below.
1. Clinical Trials
2. Angiogenesis (blood vessel growth)
3. Cellular Therapeutics
4. Regenerative Medicine
5. Wound Healing
Work in these areas is designed to decrease the limb amputation rate, accelerate healing of chronic wounds in the elderly and those with diabetes, and increase patient safety by decreasing Stage III and IV pressure ulcers.
Areas of Experience
Wound Healing & Regenerative Medicine
1. Brem H, Maggi J, Nierman D, Rolnitzky L, Bell D, Rennert R, Golinko M, Yan A, Lyder C, Vladeck B: High Cost of Stage IV Pressure Ulcers. American Journal of Surgery. 2010; 200:473-477.
2. Pastar I, Stojadinovic O, Krzyzanowska A, Barriento S, Stuelten C, Zimmerman K, Blumenberg M, Brem H: Tomic-Canic M. Attenuation of the transforming growth factor beta-signaling pathway in chronic venous ulcers. Molecular Medicine 2010; 16:92-101.
3. Golinko MS, Margolis DJ, Tal A, Hoffstad O, Boulton AJ, Brem H: Preliminary development of a diabetic foot ulcer database from wound electronic medical record: a tool to decrease limb amputations.Wound Repair Regeneration 2009; 17:-657-65.
4. Brem H, Kodra A, Golinko MS, Entero H, Stojadinovic O, Wang V, Sheahan C, Weinberg A, Woo S, Ehrlich HP, Tomic-Canic M: Mechanism of sustained release of VEGF in accelerating experimental diabetic healing. Journal of Investigative Dermatology 2009; 129:2275-2287.
5. Altchek A, Hanflik A, Deligdisch L, Brem H: Cultured Bilayered Skin Allograft for Vaginal Construction. Journal of Pediatric Adolescent Gynecol 2010; 23:e5-8. Epub 2009 Sep 3.
6. Golinko MS , Joffe R, DeVinck D, Chandrasekaran E, Stojadinovic O, Barrientos S, Vukelic, S, Tomic- Canic M, Brem H: Surgical Pathology to describe the clinical margin of debridement of chronic wounds using a wound electronic medical record. Journal of the American College of Surgeons. 2009; 209:254-260.
7. Golinko MS, Clark S, Rennert R, Flattau A, Brem H: Wound emergencies: The importance of assessment, documentation and early treatment using a wound electronic medical record. Ostomy Wound Management. 2009; 55:54-61.
8. Schiffman J, Golinko MS, Yan A, Flattau A, Tomic-Canic M, Brem, H: Operative debridement of pressure ulcers. World Journal of Surgery. 2009; 33:1396-1402.
9. Rennert R, Golinko M, Yan A, Flattau A, Tomic-Canic M, Brem H: Developing and Evaluating Outcomes of an Evidence-based Protocol for the Treatment of Osteomyelitis in Stage IV Pressure Ulcers: A Literature and Wound Electronic Medical Record Database Review. Ostomy Wound Management. 2009; 55:42-53.
10. Bao P, Kodra A, Tomic- Canic M, Golinko MS, Ehrlich HP, Brem H: The Role of VEGF in Wound Healing. Journal of Surgical Research. 2009; 153:347-358.
11. Rennert R, Golinko MS, Kaplan D, Flattau A, Brem H: Standardization of wound photography utilizing the Wound Electronic Medical Record. Advances in Skin & Wound Care 2009; 22:32-38.
12. Brem, H., Golinko MS, Stojadinovic O, Kodra A, Diegelmann RF, Vukelic S, Entero H, Coppock DL, Tomic-Canic M: Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and est putative growth factor therapy such as GMCSF. Journal of Translational Research. 2008; 6:75.
13. Golinko MS, Cox D, Martinez L; Joffe R, Chandrasekaran E, Brem H: Operative debridement of diabetic foot ulcers. (written paper and video) Journal of the American College of Surgeons 2008; 207:e1-6.
14. Flattau A, Schiffman J, Lowy F, Brem H: Antibiotic-Resistant Gram-Negative Bacteria in Deep Tissue Cultures. International Wound Journal 2008; 5: 599-600.
15. Tomic-Canic M, Ayello EA, Stojadinovic O, Golinko MS, Brem, H: Using gene transcription patterns (bar coding scans) to guide wound debridement and healing. Advanced Skin Wound Care. 2008; 21:487-92.
As a wound specialist, I’ve spent my career using biological principles to promote the healing of diabetic foot ulcers and other chronic wounds. It is my philosophy that, with proper treatment, every wound can heal.
I am currently Chief of Wound Healing and Regenerative Medicine at Winthrop-University Hospital in Mineola, New York—an institution with an exceptionally strong commitment to the training of clinical researchers.
If you are interested in becoming a clinical researcher in our training program, I encourage you to contact me by e-mail at: HBrem@winthrop.org
I can also be reached by phone at: (516) 663-8242
Patients who wish to consult with me or one of Winthrop-University Hospital’s other wound specialists can schedule an appointment by calling the Winthrop Wound Healing Center and Hyperbaric Medicine Program at: (516) 663-8498.
—Harold Brem, MD, FACS