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Obesity Research

Over the past 20 years, obesity has reached epidemic proportions and become a serious public health issue in this country in adults as well as children, who have a 70 percent chance of becoming overweight adults.

  • Overweight and obese adults, children and teens are significantly at risk for Type 2 diabetes, high blood pressure, high cholesterol, heart disease, stroke, gall stones, breathing and sleep disorders, orthopedic difficulties, and serious emotional problems stemming from social discrimination.
  • Almost 24 percent of children ages two-to-19 are obese.
  • Eight out of 10 individuals over age 25 are overweight.
  • In 2009, only Colorado and Washington, DC had a prevalence of obesity under 20 percent.
  • Obesity is often linked to poor nutrition and lack of exercise. All these are continually being shown to have important negative consequences
Source: Centers for Disease Control and Prevention, National Health and Nutrition Examination Survey

At Winthrop-University Hospital, basic scientists and clinicians are collaborating to investigate mechanisms responsible for the development of cardiovascular complications in a wide range of conditions, including obesity. Examining the regulation of certain signaling proteins in obesity, they are using a variety of biochemical methodologies, including molecular biology, array technology, tissue culture, histopathology and transgenic animals in their research. Current studies include: links between obesity and diabetes, intrauterine growth restriction and the propensity toward obesity, alterations in cytokine and gene expression in obesity, obesity and non-alcoholic fatty liver disease and animal models of obesity and bone loss. We are collaborating with other NYC area academic medical centers to design and implement school-based lifestyle improvement programs for children and teens.

WUH Researchers' Study:

  • Effects of fitness/education in an ethnically diverse student-aged and adolescent student populations in New York.
  • The pathophysiology of renal disease in obese individuals
  • The regulation of adipose tissue in obese individuals with and without diabetes
  • Effects of dietary restriction weight loss on bone density in obese subjects and rodent model.
  • Effects of Vitamin D supplementation requirements in obese subjects
  • The metabolism in medication changes with medical weight loss.
  • Rodent models to evaluate effects of dietary restrictions on bone and mineral metabolism