Drug May Help Prevent Lung and Brain Damage in Premature Babies
Winthrop Physician Oversees Multinational Studies


Vol. 9, No. 3
December, 1999

  • External Beam Radiation Therapy Makes a Quantum Leap

  • Ambulatory Surgery Unit Expands

  • New Island Hospital Breaks Ground

  • Winthrop is Y2K Ready

  • Indigo Laser Relieves Symptoms of Benign Prostate Hyperplasia

  • Rheumatoid Arthritis Study

  • Dr. Scott Named Heart Association President

  • New Interventional Radiology Suite Unveiled

  • Mammotome® Breast Biopsy Procedure

  • Drug May Help Prevent Lung and Brain Damage in Premature Babies

  • Winthrop Nurses Never Stop Learning

  • Clinical Trial for Pancreatic Cancer

  • Winthrop: A Center for Lifesaving Autologous Stem Cell Transplants

  • Carnival in Venice Benefits Winthrop

  • John Broder Named Businessperson of the Year

  • Yuletide Ball

  • Winthrop’s Ninth Annual Flu Immunization Program Reached 1,500 Senior Citizens

  • Teens for Tots/Teen Angels’ Donation to Child Life Program

  • Winthrop’s Deserving Volunteers Receive Awards

  • Volunteers Needed at Winthrop

  • Visiting Scholar from Taiwan Studies at Winthrop

  • For Long Island Children who don't have Health Insurance

  • Copyright

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  • Jonathan Davis, MD, Chief, Division of Neonatology and Co-director of Winthrop's CardioPulmonary Research Institute - the CPRI - provides expert care for ill and premature newborns, in addition to spearheading ground breaking research to improve the outcome for those babies at highest risk.


    Life without breathing cannot long be sustained, and the consequences to newborns can be particularly severe. At Winthrop, skilled medical scientists conduct clinical research to learn how to prevent long term impairment of delicate neonates who may be at great risk.

    Two significant complications associated with breathing problems in premature infants are permanent brain and lung damage. Studies have shown that an anti-oxidant delivered directly into the lungs of premature newborns demonstrates great promise in limiting long term lung and brain injuries, according to Jonathan Davis, MD, Chief, Division of Neonatology at Winthrop. Dr. Davis, who is also the Co-director of Winthrop’s CardioPulmonary Research Institute — a Hospital laboratory, staffed with PhD-level scientists, which conducts basic scientific research in heart-lung diseases — has been the lead investigator for multi-center national studies of this new, genetically engineered protein since its initial clinical trials began six years ago.

    “Winthrop is becoming recognized nationally as a leading site for cutting-edge research into this new and exciting technology,” Dr. Davis said. “We are involved in the development of products that will become the standard of care in the new millennium.”

    Superoxide dismutase is a recombinant protein created in the laboratory by inserting a human gene into harmless bacteria. As the bacteria replicate, the protein is also reproduced. Dr. Davis is enthusiastic about superoxide dismutase because preliminary indications demonstrate its potential for protecting both the brain and lungs.

    It appears to work by helping to prevent damage from excessive amounts of oxygen in the neonate. “Before birth, oxygen levels are relatively low,” Dr. Davis explained. “When babies are born extremely premature, they need to breathe oxygen, but too much can be harmful, as can not enough.”

    Without treatment, these premature babies are at increased risk for developing chronic lung problems such as bronchopulmonary dysplasia, asthma, and neurological abnormalities.

    Final data analysis on the results of a 20-site national study is being completed. “Our investigation will next expand to Europe, Asia, and the Middle East,” Dr. Davis commented. In the most recent study, babies were followed until they reached a corrected age of one year. (“Corrected age” refers to the subtraction of the number of weeks of prematurity from the baby’s actual age. For example, a baby born 10 weeks premature would, at 62 weeks of life, have a corrected age of one year.) If subsequent studies confirm these promising findings, Dr. Davis expects that superoxide dismutase could be approved for use sometime within the next five years.

    Dr. Davis has been invited to lecture on the CardioPulmonary Research Institute’s research in superoxide dismutase at professional medical meetings in San Francisco, California; Paris, France; and Athens, Greece. He is also heavily involved in ground breaking clinical trials of a variety of technologies to treat a multitude of problems in premature newborns. Access to these promising therapies is another advantage available to newborns at Winthrop — in addition to compassionate nursing care in Winthrop’s Neonatal Intensive Care Unit.

    “Participation in these trials helps us to deliver the most advanced care to our patients,” Dr. Davis concluded.



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