Neonatologist Awarded $2.186 Million for Multi-center Study


Vol. 10, No. 3
September, 2000

  • Photodynamic Therapy: A Ray of Hope for Cancer Patients

  • Baclofen Pump Relieves Severe Muscle Stiffness

  • New Intervention Helps Seal Spinal Fractures

  • Winthrop’s Program of Radiography Accepts Applications

  • The Pediatric Special Care Unit
    A Regional Resource for Children Requiring Intensive Care

  • Neonatologist Awarded $2.186 Million for Multi-center Study

  • Prostate Cancer Screening Planned

  • Ambulatory Surgery Unit Now Operational

  • Parent Alert: Four-to-Eight-Year-Olds Need Booster Seats in Cars

  • New Poison Control Website

  • October is Breast Health Month

  • September is Gynecologic Cancer Awareness Month

  • Nurse Specialist Group
    An Educational Resource

  • More than 500 Celebrate Cancer Survivors Day

  • Board Member Theodora Hooten Receives Trustee of the Year” Award

  • New Conference Center and Library Dedicated

  • “Evidence-Based Medicine” Training Grant

  • Winthrop President and CEO Honored by Metropolitan Health Administrators’ Association

  • Hospital Volunteers Needed

  • An Enchanted Evening

  • Copyright

    Back to Publications


  • Jonathan Davis, MD, Director of Neonatology and Newborn Medicine, is also the Director of the Hospital’s CardioPulmonary Research Institute.
    Piny, premature babies born with significant lung problems are usually in serious danger of developing lifelong pulmonary and neurological damage. Winthrop neonatologist Jonathan Davis, MD and a team of scientific researchers he directs in Winthrop’s CardioPulmonary Research Institute (CPRI) have been awarded major grants for their ground breaking research to prevent these problems.

    Dr. Davis, Winthrop’s Director of Neonatology and Newborn Medicine, recently concluded a comprehensive trial of the beneficial effects of an antioxidant protein, superoxide dismutase, on the lungs of premature babies. The apparent success of the trial has generated enough interest and enthusiasm at the National Institute of Health (NIH) to merit an additional grant of $2.186 million to proceed with the next component of the study. This funding also derives from the National Heart, Lung, and Blood Institute (NHLBI). The new study, with Dr. Davis as Principal Investigator, will be conducted primarily at Winthrop, in conjunction with research teams from the University of Pennsylvania and Temple University, through June 30, 2005.

    The first trial was a 20-site national study, which reasonably demonstrated the protection afforded by the delivery of superoxide dismutase into the lungs of tiny, premature newborns. This protein, normally produced in healthy lungs, can now be constituted in the laboratory. Lung and brain problems have been significantly decreased in premature babies who received the protein soon after birth.

    “The new grant will enable our team to research and further refine methods to more perfectly formulate superoxide dismutase in the laboratory; to develop better ways to deliver it to the infants’ lungs; and to improve the ways in which it works,” said Dr. Davis.

    Right now, the recombinant protein cell is delivered directly into the lungs of premature newborns through mini-catheters. Treatment with superoxide dismutase is preventing chronic lung problems such as bronchopulmonary dysplasia, asthma, and neurological abnormalities.

    CC10 Research at Winthrop.
    Additionally, Dr. Davis has been named Principal Investigator and recipient of $125,000 for research from the NIH, NHLBI, and Claragen, Inc., for further studies of CC10.

    CC10 is the shorthand name of the Clara cell protein, also normally produced in a healthy lung, now made in the laboratories of Claragen, Inc., a biotechnical corporation. In cases where the Clara cell protein is deficient in premature babies, the recombinant Clara cell, CC10, can be introduced into the lungs.

    “It is now possible to safely combine more than one artificially produced protein in the treatment of premature babies’ lungs,” Dr. Davis explained. The Winthrop CPRI research team experiments with various combinations to determine the best regimen for each patient.

    “Winthrop is proud to be leading the development of recombinant proteins that will become the standard of care in the future,” concluded Dr. Davis.

    For more information, call Dr. Davis at (516) 663-3853.



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