Inflammation, the release of white blood cells into the blood or tissues in an attempt to rid the body for foreign substances, is being recognized as the basis of many physiological and pathological processes.
- Inflammation — and diseases associated with inflammation — currently affect more than 50 percent of American men, women and children of all ages.
- Inflammation is being linked to a growing array of illnesses, e.g. there may be a connection between sudden cardiac death and rheumatoid arthritis.
- Inflammation, as part of an autoimmune disorder, can affect internal organs, including the heart, lungs, kidneys and large intestine.
At Winthrop-University Hospital, researchers are investigating the impact of inflammation on the body, including the role of inflammation as a source of atherosclerosis and in Crohn’s disease. A recent study at Winthrop uncovered the reasons behind the increased risk for heart attack among users of COX inhibitors, such as VIOXX.
WUH Researchers’ Study:
- Effects inflammation on intrauterine development
- Inflammatory responses to RSV infection invitro
- Environmental triggers such as bacterial infections and toxins.
- Activation of premature labor mechanism
- Mechanisms linking autoimmune disorders such as systemic lupus erythematosus or atherosclerosis
- Effects of pain-relieving medications that work through cyclo-oxygenase (COX) inhibition on risk of cardiovascular events such as myocardial infarction and stroke.
- Therapeutic strategies to prevent and treat the accelerated atherosclerosis that occurs in patients with prolonged use of COX inhibitors.