Bone Mineral Research

Research Interests

Faculty / Staff

Recent Publications

Contact Information

Research Interests:

The Bone Mineral Research Center focuses on both clinical and basic science aspects of bone metabolism. The basic science Metabolism Lab examines pathogenic mechanisms responsible for the development of skeletal fragility and osteoporosis. Using a wide range of biochemical methodologies including molecular biology and tissue culture, histopathology and transgenic animals, investigators examine the influence of various regulatory factors on the skeleton. In addition, by identifying the defects in diseased states, they hypothesize and test the potential sites for drug development.

The clinical research center (Osteoporosis, Diagnosis, Treatment and Research Center) is responsible for the development of various treatment modalities (nutritional and pharmacologic) for osteoporosis. The center has been involved in three major NIH sponsored trials and multiple pharmaceutical trials.

Faculty / Staff:

John F. Aloia, M.D., Director

Mageda B. Mikhail, M.D., Associate Director

James Yeh, Ph.D., Director, Metabolism Lab

Jane Greensher, R.N., Study Coordinator

Sharon Sprintz, BSRT, LRT, CDT, Densitometry Technician

Recent Publications:

Aloia JF, Vaswani A, Feuerman M, Mikhail M, Ma R. Differences in skeletal and muscle mass with aging in black and white women. American Journal Physiol Endocrinol Metab 278: E1153-E1157, 2000.

Tollin S, Perlmutter S, Aloia JF. Serial Changes in Bone Mineral Density and Bone Turnover After Correction of Secondary Hyperparathyroidism in a Patient with Pseudohypoparathyroidism Type Ib*. Journal of Bone and Mineral Research, Vol 15, Number 7, 2000.

Iwamoto J, Yeh JK, Aloia JF. Effect of Deconditioning on Cortical and Cancellous Bone Growth in the Exercise Trained Young Rats. Journal of Bone and Mineral Research, Vol 15, Number 9, 2000.

Evans JF, Yeh JK, Aloia JF. Osteoblast-like cells of the hypophysectomized rat: a model of aberrant osteoblast development. Am J Physiol Endocrinol Metab 278: E832-E838, 2000.

Tollin SR, Perlmutter S, Aloia JF. Serial changes in bone mineral density and bone turnover following correction of secondary hyperparathyroidism in a patient with pseudohypoparathyroidism, J Clin Endo & Metab, 2000 15(7):1412-1416.

Yeh JK, Niu Q, Evans JF, Iwamoto J, Aloia, JF. Effect of circular motion exercise on bone modeling and bone mass in young rats: An animal model of isometric exercise. Journal of Musculoskeletal & Neuronal Interactions, Vol 1, Number 3, March, 2001.

Arunabh, S, Feuerman, M, Ruimei, M, Aloia, JF. Total body phosphorus in healthy women and ethnic variations. Metabolism, Vol 51, No 2 (February), 2002: pp 180-183.

Arunabh S, Pollack S, Yeh J, Aloia JF. Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab. 88(1):157-161, 2003.

Appiagyei-Dankah Y, Tapiador C, Evans JF, Castro-Magana M, Aloia JF, Yeh JK. Influence of growth hormone on bone marrow adipogenesis in hypophysectomized rats. Am J Physiol Endocrinol Metab 284(3):E566-E573, 2003.

Wang Z, Shen W, Kotler DP, Heshka S, Wielopolski L, Aloia JF, Nelson ME, Pierson, RM and Heymsfield SB, Total body protein: a new cellular level mass and distribution prediction model 1-3. Am J Clin Nutr, 78: p. 979-84, 2003.

ZiMian W, Shen W, Kotler D, Heshka S, Wielopolski L, Aloia JF, Nelson M, Pierson Jr. R, Heymsfield SB. Total-body protein: A new cellular level mass and distribution prediction model. Am. J. Clin. Nutr 78(5):979-84, 2003.

Evans JF, Niu QT, Canas JA, Shen CL, Aloia, JF, Yeh JK. ACTH enhances chondrogenesis in multipotential progenitor cells and matrix production in chondrocytes. Bone 35(1):96-107, 2004.

Silva AM, Shen W, Wang Z, Aloia JF, Nelson ME, Heymsfield SB, Sardinha LB, Heshka S, Three-compartment nodel: critical evaluation based on neutron activation analysis. Am J Physiol Endocrinol Metab, 287(5):p. E962-9, 2004.

Evans JF, Shen CL, Pollack S, Aloia JF, Yeh JK. Adrenocorticotropin evokes transient elevations in intracellular free calcium (Ca+2) and increases basal (Ca2+) in resting chondrocytes through a phospholipase-C-dependent mechanism. Endocrinology, 146(7): p. 3123-32, 2005.

Aloia JF, Talwar SA, Pollack S, Yeh J. A randomized controlled-trial of vitamin D3 supplementation in African-American women. Arch Intern Med, 165 (14): p. 1618-23, 2005.

Aloia JF, Feuerman M, Yeh JK. Reference range for serum parathyroid hormone. Endocr Pract.12 (2), 2006.

Aloia JF, Talwar SA, Pollack S, Feuerman M, Yeh J. Optimal vitamin D status and serum parathyroid hormone in African American women. Am J Clin Nutr, 84(3): p. 602-9, 2006.

Contact Information:

John F. Aloia, M.D., Director
Bone Mineral Research Center
Winthrop-University Hospital
222 Station Plaza North
Suite 350
Mineola, NY 11501
Phone: (516) 663-2772
Email: jaloia@winthrop.org