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CornerStone Vol. 26, No.1, Spring/Summer 2016
Front page...

A Second Miracle for Allison
Revolutionary Heart Procedure Provides New Treatment for Sufferers of Aortic Valve Stenosis
WATCHMAN: A New Treatment Option for Patients with Atrial Fibrillation
Lifesaving Procedure and Wedding Bells for Patient with Rare Heart Condition
New, State-of-the-Art Trauma Center Opens
Committed to the Fight against Obesity
Empowered to Educate: Women with Heart Disease Fight Back
American Heart Association Awards Grant-in-Aid to Winthrop Researchers
Diabetes Prevention Program: Motivating Local Residents to Change Their Lives
24th Annual Gala Raises More than $1,000,000
Celebrating Service and Philanthropy: Special Room Dedication Held for Esteemed Physician
Getting into the Spirit at Winthrop’s Cancer Center for Kids
Annual Golf Outing Benefits the CCFK
Bo Jackson Brings Special Memories
Gregg’s Wings Foundation Continues Support
CCFK Patients Rock at Seventh Annual Rock2Beat Pediatric Cancer
Local Kiwanis Club Continues Longtime Support
CCFK Crosses the Finish Line
A Cause to Celebrate Raises Nearly $115,000 for Child Life Program
Good for the Brain: Unique Art Expressions Group Brings Patients and Caregivers Together
A Family Tradition of Philanthropy
Unique Toilet Training Program Helps Youngsters ‘Go’
New Mural Brightens Walls and Lifts Spirits
New Chiropractic Collaboration Provides Coordinated Care for Patients
Winthrop Nurses Earn Prestigious Magnet Recognition
New Member Elected to Winthrop’s Board of Directors
New Electronic Medical Record Set to Go Live This Summer
Raising the Bar for Care with National Recognitions
Yuletide Ball Raises $207,000 for Child Life Program
A Bite of Hope for Pediatric Diabetes Patients
Celebrating a 23-Year Partnership
Amanda Styles Cirelli Foundation Supports Winthrop’s Cancer Center for Kids
Floreine J. Winthrop’s Memory Honored with Tranquil Garden
Senator Martins Spreads Cheer Among Young Patients
Preventing Heat-Related Illness
Winthrop Researchers Advocate for 9/11 First Responders Suffering from Debilitating Neurological Condition
A Special Evening of Tasting and Giving Supports Pediatric Patients

American Heart Association Awards Grant-in-Aid to Winthrop Researchers

“It takes a village,” said Winthrop researcher Allison Reiss, MD, as she and her team gathered recently to celebrate receiving a Grant-in-Aid from the American Heart Association (AHA). The grant, titled, “Methotrexate and Cholesterol Transport Regulation: Impact of Treatment Regimen in Diabetes and Metabolic Syndrome,” poses the question: “Will reducing inflam- mation prevent a second heart attack?” and is designed to assess the impact of low dose methotrexate (a widely used anti-inflamma- tory therapy for rheumatoid arthritis (RA)) on cholesterol transport in the body. Dr. Reiss is the Principal Investigator, with co- investigators Alan Jacobson, MD, Chief Research Officer at Winthrop; Joshua De Leon, MD, Director of the Cardiovascular Training Program, Director of Nuclear Cardiology and Director of Cardiovascular Research; and Steven Carsons, MD, Chief of the Division of Rheumatology, Allergy and Immunology.

Pictured inside of Winthrop’s new Research and Academic Center are (l.-r.) Deborah Whitfield, Director, Clinical Trials Center at Winthrop; Donald Brand, PhD, Director, Health Outcomes Research; Joshua De Leon, MD, Director of the Cardiovascular Training Program, Nuclear Cardiology and Cardiovascular Research; Allison Reiss, MD, Head, Inflammation Section at the Winthrop Research Institute; Steven Carsons, MD, Chief of Rheumatology, Allergy and Immunology; Ellen Eylers, MPH, MSN, RN, Research Coordinator, Cardiology; Wendy Drewes, BSN, RN, CCRC, Research Coordinator, Cardiology; and Alexander Schoen, MBA, Director, Office of Sponsored Programs at Winthrop.

“We have an amazing team effort and approach here at Winthrop and we couldn’t have achieved this honor without each indi- vidual,” said Dr. Reiss, crediting the research associates, technicians, coordinators and everyone who also helped make the grant possible (see sidebar).

“This is a potential game-changer in the way we treat heart attacks, especially those in people with diabetes or at a high risk for diabetes because of metabolic syndrome,” said Dr. Jacobson. Dr. Jacobson describes Dr. Reiss’s work as “invaluable.” “It really plays into the potential underlying mechanisms of why this drug – methotrexate – might work and goes to the core of the underlying biological mechanism of the study,” he said.

In addition to Dr. Reiss, Dr. De Leon, Dr. Carsons and Dr. Jacobson, the follow- ing people were instrumental in achieving the grant:
Darnice Fulton, Secretary, Winthrop Cardiology Associates, PC
Debbie Famigletti, Administrative Coordinator, Division of Rheumatology, Allergy & Immunology Lora Kasselman, PhD, Research Associate, Winthrop Research Institute
Nicolle Siegart, Research Technician, Winthrop Research Institute
Carla Lyons, Executive Assistant to Dr. Jacobson Ellen Eylers, MPH, MSN, RN, Research Coordinator, Department of Cardiology
Wendy Drewes, BSN, RN, CCRC, Research Coordinator, Department of Cardiology
Donald Brand, PhD, Director, Health Outcomes Research
Melissa Fazzari, PhD, Director, Department of Biostatistics
Heather Renna, Research Technician, Winthrop Research Institute
Alexander Schoen, MBA, Director, Office of Sponsored Programs
Hirra Arain, Student Volunteer, Winthrop Research Institute
Samiraly Moosa, MD, Research Volunteer, Winthrop Research Institute
Deborah Whitfield, Director, Clinical Trials Center

The grant builds on the work Dr. Reiss and her team at Winthrop began in 2014 as part of a major study funded by the National Institutes of Health (NIH) called the Cardiovascular Inflammation Reduction Trial (CIRT), which had a similar goal to that of the recent grant. Through this study, Dr. Reiss and her team have been investigating whether taking low dose methotrexate reduces cardiovascular events in individuals with type 2 diabetes or metabolic syndrome who have had a heart attack or multiple coronary blockages. The recent grant awarded to the team signals the start of a sub-study that will be even more in-depth, making Winthrop an “independent and innovating contribu- tor to the science,” according to Dr. Reiss.

“It gives us the opportunity to answer the ‘why,’ ‘how,’ and ‘what’ is happening in the blood in regards to methotrexate that is protecting patients,” said Dr. Reiss. “Through this research, we can determine how patients can be best treated and how people handle the drug.”

Dr. De Leon is the leader of the clinical aspect of the project, identifying cardiology patients for the trial, and Dr. Carsons lends an immunological perspective from his experience as a rheumatologist who works with methotrexate in his arthritis patients.

“One of Winthrop’s strengths rests in its ability to bridge the laboratory and the bedside,” said Dr. De Leon. “This group has been so innovative in generating new knowl- edge and discovering the role of inflammation in altering how the cell handles cholesterol at the basic level, and how inflammation worsens atherothrombosis (the hardening and narrowing of the body’s arteries). This grant is the next step in translating all these years of basic research to patient care.”

“Our team’s unique ability to study the molecular interface between inflammation in the body and the development of heart disease has led to this important approach to cardiovascular disease prevention,” said Dr. Carsons. The results of this study have the potential to open up new ways to treat car- diovascular disease and come up with a mechanism to identify patients who will respond best to the treatment.

Dr. Reiss (second from left) gathers with her team to celebrate the American Heart Association grant.

“It means so much to be funded by the American Heart Association, a prestigious and renowned organization that has made so many contributions to allocating funds for heart disease and preventing heart attacks,” said Dr. Reiss. “We are looking forward to honoring this incredible award and doing this work to make a substantial contribution to medical knowledge of patient care.”